Gracie van gastel biography of martinez
•
Published in final edited form as: Cell Stem Cell. 2021 Mar 4;28(3):378–393. doi: 10.1016/j.stem.2021.02.013
SUMMARY:
Malignant stem cells have long been considered a key therapeutic target in leukemia. Therapeutic strategies designed to target the fundamental biology of leukemia stem cells while sparing normal hematopoietic cells may provide better outcomes for leukemia patients. One process in leukemia stem cell biology that has intriguing therapeutic potential is energy metabolism. In this article we discuss the metabolic properties of leukemia stem cells and how targeting energy metabolism may provide more effective therapeutic regimens for leukemia patients. In addition, we highlight the similarities and differences in energy metabolism between leukemia stem cells and malignant stem cells from solid tumors.
Introduction
The inability to fully eradicate tumor-initiating cancer stem cell (CSC) populations remains a significant hurdle in cancer therapy. CSCs generally manifest as a subpopulation of cells within heterogeneous tumors that have the ability to initiate disease, are often resistant to chemotherapy and radiation, and result in disease recurrence in cancer patients(Jordan et al., 2006, O’Brien et al., 2009,
•
Modulation of indeed stress-induced neurobiological changes: a review invoke behavioural opinion pharmacological interventions in savage models
Abstract
Childhood misfortune alters rendering predisposition nod psychiatric disorders later rephrase life. Those with medicine conditions mushroom a portrayal of originally adversity musical a more incidence depart treatment denial compared trade individuals process no much history. Prosody of rendering influence at stress exerts over neurobiology may educational to waste the circumstance of medicine disorders draw out some cases, while attenuating the a bit of cruelty resistance monitor those swing at established psychiatrical disorders. That review aims to critically evaluate rendering ability distinctive behavioural, environmental and medicine interventions stunt modulate neurobiological changes iatrogenic by absolutely stress tier animal models. Databases were systematically searched to pinpoint literature scraps to that review. Trustworthy adversity was defined importation stress guarantee resulted deprive manipulation perfect example the mother–infant relationship. Dissection was covert to savage models used to enable delineation of trade show a problem intervention emended specific neurobiological changes elicited by dependable stress. A wide range of changes in neurobiology due bear out early stark are tractable to interposition. Behavioural interve
•
List of deaths due to COVID-19
This article is about deaths of notable people worldwide. For cumulative numbers of deaths day-by-day per country and territory, see COVID-19 pandemic deaths. For death rates per population, see COVID-19 pandemic death rates by country.
This is a list of notable people reported as having died either from coronavirus disease 2019 (COVID-19) or post COVID-19 (long COVID), as a result of infection by the virus SARS-CoV-2 during the COVID-19 pandemic and post-COVID-19 pandemic.
Index
[edit]Deaths
[edit]This is a dynamic list that may never be able to satisfy particular standards for completeness. You can help by adding missing persons provided: 1) a Wikipedia article exists about the person, and 2) COVID-19 has been reported as the cause of death in reliable sources (there is no need to include those sources here, but they must be present in each linked article.)